文章摘要
Effect of BIIR with Additives and Mixing Process on Scorch Safeties of Medical Rubber Stopper Compounds
Received:May 28, 2024  Revised:May 28, 2024
DOI：10.12136/j.issn.1000-890X.2026.03.0206
Key Words: BIIR；medical rubber stopper；mixing process；scorch safety
Author NameAffiliationE-mail
GAO Song* Shandong Chambroad Sinopoly New Materials Co.，Ltd 59gaosong@163.com 
ZHANG Shuhua Shandong Chambroad Sinopoly New Materials Co.，Ltd  
HAO Fulan Shandong Chambroad Sinopoly New Materials Co.，Ltd  
HAN Fei Shandong Chambroad Sinopoly New Materials Co.，Ltd  
LI Lange Shandong Chambroad Sinopoly New Materials Co.，Ltd  
ZONG Xin Shandong Chambroad Sinopoly New Materials Co.，Ltd  
ZHANG Min Shandong Chambroad Sinopoly New Materials Co.，Ltd  
LIU Xiao Shandong Chambroad Sinopoly New Materials Co.，Ltd  
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Abstract:
      The effects of brominated butyl rubber（BIIR） with additives and mixing process on the scorch safeties and other properties of BIIR medical rubber stopper compounds were studied.The results showed that，the calcium stearate and epoxidized soybean oil contents of BIIR had minimal effects on the scorch safety of BIIR medical rubber stopper compounds.Although antioxidant 1076 could extend the scorch time of BIIR medical rubber stopper compound，but its required dosage was larger，which had a negative impact on the compatibility between the medical rubber stopper and drug.Adjusting the mixing process by adding magnesium oxide in the first-stage mixing and lowering the first-stage mixing discharge temperature，both effectively extended the scorch time of BIIR medical rubber stopper compound without significantly affecting the physical properties of the compound and compatibility between medical rubber stopper and drug.
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