文章摘要
Determination of Migration Amounts of N-nitrosamine Substance in Silicone Pacifiers for Infants and young children and Analysis of Their Exposure Risks
Received:March 27, 2023  Revised:March 27, 2023
DOI：10.12136/j.issn.1000-890X.2025.03.0220
Key Words: silicone pacifiers for infants and young children；N-nitrosamines substances；oral exposure mathematical model；simulating artificial saliva migration；GC-MS
Author NameAffiliationE-mail
CHEN Dewen* 杭州职业技术学院 42030692@qq.com 
GONG Xudong 义乌市产品（商品）质量检验研究院  
ZHU Binchao 义乌市产品（商品）质量检验研究院  
WANG Zhenglin 义乌市产品（商品）质量检验研究院  
WU Min 杭州职业技术学院  
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Abstract:
      A method for determining the migration amounts of 12 N-nitrosamine substances in silicone pacifiers for infants and young children，the oral exposure mathematical model was used to assess the exposure risk of N-nitrosamine substances in pacifiers.After simulating artificial saliva migration and extraction of pacifier samples，extracting N-nitrosamine substances used dichloromethane as a solvent，N-nitrosamine substances were analyzed using gas chromatography-mass spectrometry（GC-MS）.The results showed that the quantification limits for the detecting the 12 N-nitrosamines substances in the mixed standard solution were 0.027～0.031 mg·L-1，with recovery rates of 86.9%～120.0% and relative standard deviations of 4.25%～8.31%.The N-nitrosamines substances with the highest content and occurring frequenly in pacifiers were N-nitrosobenzylamine and N-nitroso-N-methylaniline，respectively.According to the oral exposure mathematical model calculation，the daily intake of N-nitrosamines substances by infants and young children through contacting pacifier was significantly below the tolerable daily intake levels.
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