| 含助剂溴化丁基橡胶和混炼工艺对医用胶塞胶料焦烧性能的影响 |
| Effect of BIIR with Additives and Mixing Process on Scorch Safeties of Medical Rubber Stopper Compounds |
| 投稿时间：2024-05-28 修订日期：2024-05-28 |
| DOI：10.12136/j.issn.1000-890X.2026.03.0206 |
| 中文关键词: 溴化丁基橡胶 医用胶塞 混炼工艺 焦烧性能 |
| 英文关键词: BIIR medical rubber stopper mixing process scorch safety |
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| 中文摘要: |
| 研究含助剂溴化丁基橡胶（BIIR）和混炼工艺对BIIR医用胶塞胶料焦烧性能及其他性能的影响。结果表明：BIIR的硬脂酸钙和环氧大豆油含量对BIIR医用胶塞胶料的焦烧性能影响较小；抗氧化剂1076虽然能够延长BIIR医用胶塞胶料的焦烧时间，但需用量较大，这会给医用胶塞与药物的相容性带来不利影响；调整混炼工艺，通过在一段混炼时加入氧化镁和降低一段混炼排胶温度，都能够比较理想地延长BIIR医用胶塞胶料的焦烧时间，而不会对胶料的物理性能和医用胶塞与药物的相容性产生大的影响。 |
| 英文摘要: |
| The effects of brominated butyl rubber（BIIR） with additives and mixing process on the scorch safeties and other properties of BIIR medical rubber stopper compounds were studied.The results showed that，the calcium stearate and epoxidized soybean oil contents of BIIR had minimal effects on the scorch safety of BIIR medical rubber stopper compounds.Although antioxidant 1076 could extend the scorch time of BIIR medical rubber stopper compound，but its required dosage was larger，which had a negative impact on the compatibility between the medical rubber stopper and drug.Adjusting the mixing process by adding magnesium oxide in the first-stage mixing and lowering the first-stage mixing discharge temperature，both effectively extended the scorch time of BIIR medical rubber stopper compound without significantly affecting the physical properties of the compound and compatibility between medical rubber stopper and drug. |
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