| 药用聚异戊二烯橡胶细胞毒性的研究 |
| Study on Cytotoxicity of Medicinal Polyisoprene Rubber |
| 投稿时间：2020-05-25 修订日期：2020-05-25 |
| DOI：10.12136/j.issn.1000-890X.2021.02.0134 |
| 中文关键词: 聚异戊二烯橡胶 氯化钠注射液 纯化水 浸提 显微镜 四唑盐比色法 细胞毒性 |
| 英文关键词: polyisoprene rubber sodium chloride injection purified water extraction microscope tetrazolium salt colorimetry cytotoxicity |
| 基金项目: |
|
| 摘要点击次数: 1396 |
| 全文下载次数: 845 |
| 中文摘要: |
| 以两种不同催化体系合成的药用聚异戊二烯橡胶（IR0307和IR80）为研究对象，分别以质量分数为0.9%的氯化钠注射液和纯化水为浸提介质，在两种浸提条件（在高压灭菌器内于121 ℃下浸提60 min或在密闭容器内于37 ℃下浸提24 h）下进行浸提处理，然后采用显微镜观察法和四唑盐比色法测定IR0307和IR80的体外细胞毒性，分析不同浸提条件下IR0307和IR80的细胞毒性反应等级。在药用聚异戊二烯橡胶生产中，建议控制催化剂的残留量以及对杂质和金属离子的含量和种类，使用洁净的非污染型防老剂和稳定剂。 |
| 英文摘要: |
| Medicinal polyisoprene rubber（IR0307 and IR80） synthesized by two different catalytic systems were used as the research object，when sodium chloride injection with mass fraction of 0.9% and purified water were used as extraction media respectively，IR0307 and IR80 were extracted under two extraction conditions，such as extraction at 121℃ for 60 min in autoclave or extraction at 37 ℃ for 24 h in close-container.The cytotoxicity of IR0307 and IR80 were determined by microscopic observation and tetrazolium salt colorimetry，and the cytotoxicity reaction grade of IR0307 and IR80 under different extraction conditions were analyzed.In medical polyisoprene rubber，it was suggested to control the residual amount of catalyst and the content and types of impurities and metal ions，and use clean non-pollutiong anti-aging agent and stabilizer. |
|
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
