| 天然胶乳和硅橡胶气囊导尿管的成型工艺与应用 |
| Molding Technology and Application of Balloon Catheter Made of Natural Latex and Silicone Rubber |
| 投稿时间：2020-04-14 修订日期：2020-04-14 |
| DOI：10.12136/j.issn.1000-890X.2021.07.0552 |
| 中文关键词: 天然胶乳 硅橡胶 球囊 导尿管 成型工艺 留置 生物相容性 安全性 |
| 英文关键词: natural latex silicone rubber balloon catheter molding technology retention biocompatibility security |
| 基金项目:2018年度广东省科技创新战略专项资金竞争性分配项目（2018A01004）；中国热带农业科学院基本科研业务费专项资金资助项目 （1630122017012）；广东省天然橡胶加工重点实验室专项基金资助项目（2019B121203004） |
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| 中文摘要: |
| 气囊导尿管广泛应用于临床医疗，对比天然胶乳与硅橡胶气囊导尿管的性能、成型工艺和应用。天然胶乳具有优异的综合性能，采用多次浸渍工艺可制作各种规格和型号的气囊导尿管，但天然胶乳制品生物相容性差，天然胶乳气囊导尿管临床上存在过敏症、亚硝胺诱导致癌和残留硝酸钙刺激等安全风险。硅橡胶气囊导尿管临床上生物相容性和安全性较好，置留时间较长，但价格相对偏高。两种气囊导尿管各有市场需求，预计硅橡胶气囊导尿管将逐渐替代天然胶乳气囊导尿管。 |
| 英文摘要: |
| Balloon catheters were widely used in clinical treatment．The performance，molding process and application of balloon catheter produced by natural latex and silicone rubber were compared． Natural latex showed excellent comprehensive properties，which was suitable for the multiple-stage impregnation processes to produce various types of balloon catheters with different specifications．However，the products of natural latex had poor biological compatibility．Typically，balloon catheter made of natural latex had many safety risks in clinical medicine，including allergies，nitrosamine-induced carcinogenesis and stimulations from
residual calcium nitrate． Balloon catheters made of silicone rubber had excellent biocompatibility and safety in clinic，and had long retention time，but the price was relatively high．These two kinds of balloon catheters had their own market demands，and it was expected that balloon catheters made of natural latex would be gradually replaced by those made of silicone rubber． |
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